1. Why would the Foundation advertise for Airedale samples to be sent
in to the Airedale DNA Bank?
The Foundation has created an Airedale DNA Bank as
it is the most effective means to:
1. provide the necessary DNA samples for active research studies.
2. store a
large quantity of DNA, including tissue, serum, or other types of samples, that represents the entire breed that can be used
for future research investigations.
3. build a database library of anonymous statistical information on the Airedale
breed which can: a.) provide insights to assist breeders in their breeding decisions and the care of their Airedales, or clues
for a research investigation and b.) track phenotypic traits, or environmental attributes that may be associated with a disorder
and c) allow researchers to directly communicate with the veterinarians and owners of the Airedales to collect as much info
as needed, and at age-specific times for study of diseases that have age-related points of expression.
4. to have a central location for all information about research samples and current studies which include the Airedale.
2. Why is our foundation asking owners of normal,
healthy Airedales to enter their data and donate their DNA for Research?
Most people have had a science class, where they used a "Control group" in an experiment to compare
the differences in the experiment. This is the basis of sound science. Many normal DNA samples are needed for investigators
to establish the normal, healthy, genetic sequence pattern in the Airedale breed. Once the normal sequence is established,
the investigators can compare the normal sequence to the genetic sequence of the ill Airedales. The areas where the genetic
patterns are different may indicate the gene or genes (markers) that are suspect in the development of a disease. The identification
of such gene markers would increase the speed or possibility that the investigator would have productive results.
3. Why do many research investigations ask for only ill animals, if it is better
to have both normal (control) and ill animals for a study?
Most research grants have very limited funds and that funding is approved for short periods of time. So,
the common focus is to collect as many sick animals as possible, with the limited time and limited funds available. Once there
are enough DNA samples in our Airedale bank, we would be able to send our research investigators both types of DNA samples.
This would give them a more complete picture of our breed's genetic blueprint, which could help the investigators find a treatment
or test for our breed.
4. Once I enter my animal's DNA and information
in the Bank, will its personal information ever become public?
No. If a researcher has had success, he/she may publish a scientific paper, which may refer to animals by
the researcher codes. The owner or the dog can never be identified. However, when the owner fills out the original paperwork
for the Bank, they may permit a researcher to contact them or their veterinarian for further information on that animal. Also,
from time to time, statistical analysis may be performed on the collected data (to detect trends, identify breed medical problems
etc), and those results, without any personal identifiers will be displayed on the AHF website to improve the knowledge of
5. What could I expect to get from
this anonymous statistical information that will be reported from a breed health survey or from the database in the DNA Bank?
A database can sort, track, and organize every piece of information.
When the Bank has enough Airedale DNA and its accompanying data in the database, reports can be published. Those anonymous
reports can identify trends for our owners on nutrition, vaccinations, environment, pesticides, phenotype, etc. and target
how they might impact the health of our animals. Such information can be of immediate use for an owner. Examples of this might
1. a vaccination schedule or vaccines could be identified as possible triggers for the onset of one or many disorders
2. certain food-based diets could be commonly associated with allergies or multiple disorders
3. environmental conditions
or pesticides could be implicated with the onset of one or more disorders
4. certain supplements may lower the levels
of medication or might be used as a substitute for prescription medications
5. phenotypic data could be used by breeders
to help them determine how to increase the probability that they can neutralize the development of undesirable traits or disorders
6. What security measures have been put in place to protect the identity of the animal
and the owner?
1. Each animal is assigned an Identification
Code. That Identification Code will link all information about the owner and the animal. The DNA Bank is an independent facility
and its personnel are not affiliated with any Airedale dog organization. The Identification Code and password are secured
and only accessible by the veterinarian researcher at the Bank.
2. All DNA Samples, the accompanying
pedigree, and any other documents pertaining to that animal or owner, will be released to a research facility with no identifying
information other than the Identification Code which has been assigned to it.
Why would I want to put my Airedale's DNA and data information into the DNA Bank?
1. Each Airedale has a genetic blueprint, which is a piece of the Airedale genetic
puzzle, and researchers can use its DNA to map the Airedale genetic codes.
2. Collecting information on the Airedale
breed's environment, nutrition, and vaccinations can reveal trends that could affect your Airedale's quality of life.
8. Would there be any future monetary
gain either to myself or the Foundation from the use of my animal's DNA?
No, neither the Foundation nor you would be entitled to any royalties that might result from the development
of test or treatments. The Foundation's Airedale research investigations are funded through another non-profit, like the Morris
Animal Foundation, or the university researchers, and their scientific advisory boards and grant boards make determinations
on the quality of the research study. They would sign a contract allowing grant money to be funneled to an approved investigation.
Investigating entities and universities sign contracts to benefit their principals and their organization.
9. Can DNA be extracted from stored semen on deceased Airedales?
Yes, stud dogs that were used frequently or have had great influence
in the breed would be ideal. Spent straws from frozen semen matings can be sent directly to the DNA bank after the implantation;
there is no need for special preservation or refrigeration. In this way, the valuable DNA can be extracted without wasting
any straws. Please contact Michele Perloski at Michele Perloski, Sample Coordinator, 617-714-7792, email:
10. Can non-ATCA or other breed club
members donate their Airedale's DNA to the bank?
since the purpose of the bank is to house a large cross section that is representative of the breeds' DNA, all Airedale owners
may participate by donating their dogs' DNA.
Airedale owners from outside the USA donate their Airedale's DNA?
Yes. Sample submission
to the Airedale DNA bank is open to all non-USA Airedales. Having as complete a DNA bank as possible will certainly make our
breed very attractive to research investigators. For instructions on how to send in a sample from a country outside the US,
please visit Michele Perloski, Sample Coordinator, 617-714-7792, email: email@example.com
12. Can I enter an Airedale who is not registered with any purebred registry?
13. If I enter an Airedale into the bank, can I make changes to its information or
my personal information at a later date?
http://www.broadinstitute.org/scientific-community/science/projects/mammals-models/canine-health-update-forms to update your
dog's health status.
14. Who determines how and when the DNA is
used in a research study?
Once enough samples are submitted on a particular disease, Broad Institute, through bi-annual e-newsletters, will let us know
what projects are underway, or about to start, or are in need of more samples. Communication between researchers who
are involved with sample collections and the Airedale community at large will be strong.
In the meantime, an annual update of an aggregate of results on the samples in the DNA bank will be submitted
to key canine genetics researchers to keep them abreast of the types of samples available at the DNA bank. Researchers have
access to the samples in the DNA Bank at all times. Along with the canine research community, the network with CHF, OFA,
CHIC, and the Morris Animal Foundation allows many reviews by credentialed professionals to assess which
research projects could also use the Airedale samples for study.
If my animal is entered into a research investigation, will I receive information from the researcher?
Yes. The core team of canine health researchers will be in contact with owners who have made submissions to
the Airedale DNA BAnk - to keep owners abreast of research studies. The researchers will also publish findings and needs
in a bi-annual e-newsletter available to all Airedale owner.
I submit data, but not DNA, on deceased dogs to add to the wealth of knowledge?
Yes, you may submit information on deceased dogs who do not have DNA
banked at the Airedale DNA Library to: Michele Perloski, Sample Coordinator, 617-714-7792, email: firstname.lastname@example.org.
17. Can you give me more assurance that my Dog's Information
will be confidential?
Airedale DNA Bank operates an informed consent database. All information regarding test results remain confidential unless
the owner specifically authorizes release of the information into the public domain. While owners are encouraged to release
all test results, realizing it is in the ultimate health interests of the breed and the information greatly increases the
depth and breadth of any resulting pedigree analysis, it is up to the owner to release all test results. For those not quite
ready to accept open sharing of information, there is still value in submitting their results. All test information entered
into the database is available in aggregate for research and statistical reporting purposes, but does not disclose identification
of individual dogs. This results in improved information on the prevalence of the disease, as well as information regarding
progress in reducing the incidence of the disease.