2013 Broad Newsletter
Airedale Health Research
in the process of updating the site, especially with news on the below topics. Stay tuned and keep visiting to see the
updates as they happen. We will upload changes, even small ones, often to provide new material.)
What's Been Happening in 2013:
-Renal Studies (Protein-Losing Neuropathy, Renal Dysplasia, and Other Renal Issues). The AHF participated in two Renal Studies in 2013 - Marker screening for PLN and
-Canine Hip Dysplasia - Notes from
the lastest seminars on OFA and PennHip Studies by Dr. Gail Smith and Dr. Eldin Leighton.
Study in Airedales - How you can help.
-Canine Cancer Research -
the lastest news on top cancers seen in the breed and update from the Canine Cancer Foundation, and how you can help cancer
research studies in the breed.
-Canine Working Dog Conference - October, 2013.
Notes on topics such as heritable temperament traits, newborn care tips, and reproduction findings.
-Homozygosity Study - How Inbred Are Airedales? Given that our past breeding tendencies are to use
popular sires an average of 50 times, it might be time to consider diversity within the breed. How much inbreeding is
-Reminder about Degenerative Myelopathy (DM) - It is possible to screen Airedales for the SOD1 mutation, a mutation associated with DM.
Airedale Blood Sample Submission -- Please Help!
We need your Airedale's Blood Sample for the Airedale DNA Library and we're seeking samples
on both Airedales affected with any disease and samples from Airedales without health issues.
It's easy to send in your dog's blood sample - Just click on the links below and follow the directions. Your
veterinarian will be able to draw the needed amount of blood and if you mention this is for reseaerch, your vet may offer
a discount! (It's always a good idea to ask!) It's a minimal cost to you, and priceless in terms of helping the
And Please remember -No Health Problems with your Dog? Your
Dog's Blood Sample will still help the research projects. Below are the links you'll need for instructions on how to submit
Please follow the links below for more information.
If you have additional questions, please
email@example.com or firstname.lastname@example.org.
Once again, thank you
for participating in this important research - you are contributing to the betterment of future generations.
"Since completing the sequencing of the canine
genome, the real bottleneck to understanding inheritance of disease and how to breed away from it is in getting blood samples
from dogs." Kerstin Lindblad-Toh. Dr. Lindblad-Toh leads the dog disease-mapping group at
the Broad Institute of MIT and Harvard. She and her research team are mapping over 20 diseases in the canine including cancer,
autoimmune, cardiac, and neurological diseases.
Not Sure How Research Helps Improve our Dogs' Health? Read this:
DNA Test Helps Dalmations:
is just one example of many on how Research Helps Breeders Breed Healthier Dogs:
Molecular Basis for Hyperuricosuria in the Dalmation Dog
Bladder stone disease is a painful problem for dogs
and it can sometimes require multiple surgeries. Researchers set out to determine the gene mutation that is responsible for
an inherited trait in Dalmatians that predisposes them to form bladder stones. They successfully identified the location of
the gene and discovered multiple mutations. These results also showed that other breeds, namely the Bulldog and Black Russian
Terrier, have the same mutation as the Dalmatian. In addition, other breeds appear to have the mutation at a lower frequency.
A DNA based test has been developed from this work and is now available to dog breeders and veterinarians to make better,
informed breeding decisions. The discovery of the gene mutation will allow breeders the opportunity to eliminate this condition
from all dogs. The test is available by contacting University of California, Davis. This fellowship training grant was
the basis for a promising young researcher's PhD thesis.
Principal Investigator: Dr. Noa Safra, University of California/Davis