Airedale Health Research
Juvenile Renal Dysplasia - New Information on Site.
Participation in testing is underway
- three research groups have canine renal dysplasia studies - Dogenes, Inc, Dr. Littman at University of Penn, and Dr. Lindblad-Toh
at Broad. We hope to add samples to the Airedale DNA Bank for use in Dr. Lindblad-Toh's studies (please submit your
Airedale's blood sample to the Airedale Bank).
Studies - We have had breeder requests for information on this area of study. We found two main research groups
intensively studying the subject of longevity in the different breeds versus disease. A good paper to read: Mortality
in North American Dogs from 1984 to 2004:An Investigation into Age-, Size-, and Breed-RelatedCauses of Death, J.M.
Fleming, K.E. Creevy, and D.E.L. Promislow, J. Vet. Intern. Med., 2011;25:187-198. Click here for a synopsis.
Homozygosity Study in Airedales: The results from a collaborative study with MARS Veterinary and the Optimal Selection Genetic Breeding Analysis are
in. Airedales samples from 3 kennels were studied (with dogs from 2 American kennels and 1 International kennel). The
results are enlightening. New Studies for 2013: MHC Diversity Testing
Genetics Studies on Canine Hip Dysplasia.
Calling all European Airedale Owners and Breeders!!
The Airedale Health Foundation and Broad Institute have developed an easy way for you to submit blood samples from your
Airedales. All the forms you'll need for sample submission can be found at "How to Submit A Blood Sample".
Please ship any European samples to Sweden at the following address (and please mark the envelope "Airedale
Animal Genetics Laboratory
Dept of Animal Breeding and Genetics
University of Agricultural Science
SE-750 07 UPPSALA
News Flash! November 1st, 2011
The Foundation has been working toward having a more cohevise system
of communicating and collaborating with canine geneticists and veterinarian researchers on all things concerned with Airedale
health and canine health. We have that system now! Researchers do want to communicate with Airedale owners and
breeders and they are following the results of the Airedale Health Survey. Creating of a data system housing all known Airedale DNA samples and studies that is accessible by researchers is
now in place. We also will be publishing a bi-annual e-newsletter (online only) which will contain information researchers
want to share with you. In the process, Airedale owners can contact us or the researchers directly if they have needs
or questions. Ask to be put on our mailing list if you want to receive the e-newsletter (write us at firstname.lastname@example.org
News Flash! September, 2011
The research results are in on checking samples of Airedales affected with Degenerative
Myelopathy, testing positive for the SOD1 mutation associated with the disease. It is now possible to screen Airedales
for this mutation.
Please see our "Elliot & Jake Made It Possible" page for more details.
Airedale Blood Sample Submission -- Please Help!
We need your Airedale's Blood Sample for the Airedale DNA Library and we're seeking samples
on both Airedales affected with any disease and samples from Airedales without health issues.
It's easy to send in your dog's blood sample - Just click on the links below and follow the directions. Your
veterinarian will be able to draw the needed amount of blood and if you mention this is for reseaerch, your vet may offer
a discount! (It's always a good idea to ask!) It's a minimal cost to you, and priceless in terms of helping the
And Please remember -No Health Problems with your Dog? Your
Dog's Blood Sample will still help the research projects. Below are the links you'll need for instructions on how to submit
Please follow the links below for more information.
If you have additional questions, please contact:
email@example.com or firstname.lastname@example.org.
again, thank you for participating in this important research - you are contributing to the betterment of future generations.
"Since completing the sequencing of the canine
genome, the real bottleneck to understanding inheritance of disease and how to breed away from it is in getting blood samples
from dogs." Kerstin Lindblad-Toh. Dr. Lindblad-Toh leads the dog disease-mapping group at
the Broad Institute of MIT and Harvard. She and her research team are mapping over 20 diseases in the canine including cancer,
autoimmune, cardiac, and neurological diseases.
Not Sure How Research Helps Improve our Dogs' Health? Read this:
DNA Test Helps Dalmations:
is just one example of many on how Research Helps Breeders Breed Healthier Dogs:
Molecular Basis for Hyperuricosuria in the Dalmation Dog
Bladder stone disease is a painful problem for dogs
and it can sometimes require multiple surgeries. Researchers set out to determine the gene mutation that is responsible for
an inherited trait in Dalmatians that predisposes them to form bladder stones. They successfully identified the location of
the gene and discovered multiple mutations. These results also showed that other breeds, namely the Bulldog and Black Russian
Terrier, have the same mutation as the Dalmatian. In addition, other breeds appear to have the mutation at a lower frequency.
A DNA based test has been developed from this work and is now available to dog breeders and veterinarians to make better,
informed breeding decisions. The discovery of the gene mutation will allow breeders the opportunity to eliminate this condition
from all dogs. The test is available by contacting University of California, Davis. This fellowship training grant was
the basis for a promising young researcher's PhD thesis.
Principal Investigator: Dr. Noa Safra, University of California/Davis